The Change in Business Culture Caused by the Introduction of Anglo-American Business Concepts in Post-Soviet Russia : Linguistic Evidence of Paradigm Shift in Business

関西学院大

Changes in Education under the Influence of Digital Technologies: main Problems and Risk of Division

Digital technologies are rapidly changing the process of education. Online courses have become a common tool of gaining knowledge outside the university. Multimedia education, penetrating traditional educational institutions (schools, colleges, and universities), changes the structure of education and brings new elements to the communications during the educational process. This article considers one level of change in the model of education. On the one hand, there are advantages associated with the democratization of education. At the time of their foundation, universities were the creators of new elites – scientific and educational meanwhile, in the twenty-first century, the process of democratization and the accessibility of university education has been linked to the digitalization. On the other hand, territorial and other restrictions have been lifted. And this is a very controversial process that poses many challenges for students, one of the most noticeable of which is the lack of real contact with the teacher and the transformation of the educational process into an ”educational conveyor belt.” At the same time, personal contact with the teacher is becoming more expensive. The authors have collected studies that examine the dynamics of this emerging stratification of education. Based on the work of the pioneers in the study of digital education, the authors develop their ideas, focusing on the formation of the modern models of education, defined as affordable electronic and elite traditional. Keywords: online courses, online education, MOO

PUBLIC SAFETY AND THE MAIN DIRECTIONS OF ITS PROVISION FOR THE SUSTAINABLE DEVELOPMENT OF MODERN SOCIETY

Objective: The purpose of the article is aimed at solving the modern problem associated with the legal provision of measures implemented in order to guarantee public safety on the territory of states and individual regions. The importance of solving this problem is predetermined by the search for the most optimal legal means in the field of protecting the life and health of the local population, including the legal rights of the indigenous peoples living in small numbers, natural resources, ensuring legal use of natural resources, environmental safety and etc. Methodology: The methodology of the research is based on a set of general scientific, private and special methods of scientific knowledge that allow the system to structure, subject to formal and legal means, a mechanism for conduct a comparative legal analysis, identifying general and specific trends in ensuring public security. Results: As a result of the study, it was concluded that one of the problems of ensuring public security is minimization and neutralization of these threats should contribute to the implementation in the norms and institutions of international law, aimed at increasing the level of anti-terrorist protection of places where people stay, life support facilities, transport infrastructure, organizations of fuel and energy, chemical, nuclear weapons, nuclear power and industry, defense and industry complexes of the country. Conclusion: Conclusions are made that constantly changing challenges and threats to public safety predetermine the expediency of updating the normative-legal framework, in particular the adoption of criminal law measures to counteract crime in the area under study. The practice-oriented measures proposed in the article are of importance, including conceptual directions for the implementation of solutions for the prevention, suppression and counteraction of crime that encroaches on the interests of public safety.

Simulation of the processes of drilling polymer composite blanks using digital twins

Polycrystalline composite materials made of carbon fiber reinforced plastics have more and more widespread application in mechanical engineering and become the main material for the production of modern types of high-speed transport. Thus, their share has already reached 35–45 % in the structural design of passenger aircrafts. However, the technology of machining surfaces of parts made of these materials, in particular, holes, is characterized by insufficient knowledge, the absence of regulatory standards for cutting modes and is most often based on the production experience of enterprises. When changing the processing conditions and the material, the pre-production engineering duration causes a significant increase in the cost of manufacturing parts due to the need for experimental selection of the cutting mode rational elements. To exclude the empirical selection of rational elements of the machining equipment cutting mode, the authors considered the possibility of using digital twins for studying the processes of drilling holes in the blanks made of composite materials, including those with the ultrasonic field energy introduction into the new surface shaping zone (to improve the processing quality and productivity). When modeling, the LS-DYNA program was used. The authors prepared the models and processed the results using the LS-PrePost 4.8 program. During the study, an explicit modeling method was used with preliminary validation and calibration of the results of tests of composites. The authors carried out calibration on test operations of tension, three-point bending, and interlaminar shear of the ВКУ-39 polymer composite material based on carbon fibers (carbon fiber reinforced plastic) widely used in domestic engineering. The developed finite element computer models allow simulating drilling procedures without carrying out rather complicated and expensive field tests. As a result of modeling, a simulation file was obtained, which reflects the process of drilling holes in a polymer composite material blank, as close as possible to the real-life situation with chip removal

The influence of cisplatin on transcriptional profile of tumor-associated macrophages of breast cancer and colon cancer

In the present study we demonstrated the whole transcriptome analysis of model tumor-associate

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence

HIV-1 integrase (IN) inhibitors represent a new class of highly effective anti-AIDS therapeutics. Current FDA-approved IN strand transfer inhibitors (INSTIs) share a common mechanism of action that involves chelation of catalytic divalent metal ions. However, the emergence of IN mutants having reduced sensitivity to these inhibitors underlies efforts to derive agents that antagonize IN function by alternate mechanisms. Integrase along with the 96-residue multifunctional accessory protein, viral protein R (Vpr), are both components of the HIV-1 pre-integration complex (PIC). Coordinated interactions within the PIC are important for viral replication. Herein, we report a 7-mer peptide based on the shortened Vpr (69–75) sequence containing a biotin group and a photo-reactive benzoylphenylalanyl residue, and which exhibits low micromolar IN inhibitory potency. Photo-crosslinking experiments have indicated that the peptide directly binds IN. The peptide does not interfere with IN-DNA interactions or induce higher-order, aberrant IN multimerization, suggesting a mode of action for the peptide that is distinct from clinically used INSTIs and developmental allosteric IN inhibitors. This compact Vpr-derived peptide may serve as a valuable pharmacological tool to identify a potential new pharmacologic site